EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice.
BACKGROUND: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer.With the available treatments, survival does not exceed 12-14 mo from the time of diagnosis.We describe a novel strategy to selectively induce the death of glioblastoma cells and other cancer cells that over-express the EGF receptor.Using a non-viral delivery vector t